1.1: KHMDS / tetrahydrofuran / 1 h / -78 °C 1.2: 72 percent / tetrahydrofuran / -78 - 20 °C 2.1: 66 percent / HCl / diethyl ether; CH2Cl2; H2O / 20 °C View Scheme

N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide 1.) THF, -72 deg C; 2.) -72 deg C, 10 min then -40 deg C, 3 h; Yield given. Multistep reaction;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br /> <br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: AcCl / 20 &deg;C<br />2: CH₂Cl₂ / 12 h<br /> <br /> &nbsp;