N-(苯氧基乙酰基)-3',5'-O-[1,1,3,3-四(异丙基)-1,3-二硅氧烷二基]鸟苷合成路线 （共 1 条）
反应条件
1.1: acetic anhydride; acetic acid / 16 h / 50 °C 2.1: sulfuryl dichloride / dichloromethane / 2 h / 25 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h 3.2: 24 h / 25 °C 4.1: ammonium fluoride / methanol / 16 h / 25 °C 5.1: ammonia; water / 1 h / 55 °C 6.1: methanol / 1 h / 55 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 55 °C View Scheme
参考文献
Cieslak, Jacek; Grajkowski, Andrzej; Ausin, Cristina; Gapeev, Alexei; Beaucage, Serge L.
Nucleic Acids Research, 2012 , vol. 40, # 5 p. 2312 - 2329
