N-(苯基甲基)-1,4-二氧杂螺[4.5]癸烷-8-胺合成路线 (共 8 条)
反应条件
1: With sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 20 h; 2: With sodium hydroxide in dichloromethane; water
参考文献
GRUeNENTHAL GMBH
Patent: WO2005/105759 A1, 2005 ;
Location in patent: Page/Page column 90 ;
反应条件
sodium tetrahydroborate in 1,4-dioxane T=25°C;
参考文献
Varma, Rajender S.; Dahiya, Rajender
Tetrahedron, 1998 , vol. 54, # 23 p. 6293 - 6298
反应条件
1: montmorillonite K10 clay / microwave irradiation 2: montmorillonite K10 clay; sodium borohydride; water / 0.03 h / microwave irradiation View Scheme
参考文献
Hassner, Alfred; Belostotskii, Anatoly M.
Tetrahedron Letters, 1995 , vol. 36, # 10 p. 1709 - 1712
反应条件
1: molecular sieves 4A / benzene / 4 h / Heating 2: NaBH4 / dioxane / 25 °C View Scheme
参考文献
Varma, Rajender S.; Dahiya, Rajender
Tetrahedron, 1998 , vol. 54, # 23 p. 6293 - 6298
反应条件
hydrogen; palladium dihydroxide in methanol 20 h;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Duncia, John V.; Gardner, Daniel S.; Ko, Soo S.; Srivastava, Anurag S.; Yang, Michael G.
Patent: US2005/54627 A1, 2005 ;
Location in patent: Page/Page column 47 ;
US 20050054627 A1
反应条件
hydrogenchloride in tetrahydrofuran 10 h; Heating;
参考文献
Quirante, Josefina; Escolano, Carmen; Massot, Mireia; Bonjoch, Josep
Tetrahedron, 1997 , vol. 53, # 4 p. 1391 - 1402
反应条件
potassium carbonate; potassium iodide in 1-methyl-pyrrolidin-2-one T=80°C; 24 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/98282 A1, 2011 ;
Location in patent: Page/Page column 36 ;
反应条件
1.1: K2CO3; LiI / acetonitrile / 24 h / 60 °C 1.2: 77 percent / HCl / tetrahydrofuran / 16 h / 20 °C 2.1: 10 percent / PdCl2(PPh3)2; Cs2CO3; Et3N / 24 h / 100 - 110 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 6 p. 1587 - 1594