131543-46-9合成路线 （共 480 条）
反应条件
1: formaldehyd; N-butylamine With hydrogen bromide in methanol; water
T=10°C; Modified Radziszewski reaction; 0.5 h;
2: ethane-1,2-dial in methanol; water
T=20°C; Modified Radziszewski reaction; 6 h;
参考文献
Zimmermann, Johannes; Ondruschka, Bernd; Stark, Annegret
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1102 - 1109
反应条件
triethylamine in tetrahydrofuran; water
Ambient temperature;
参考文献
Yoshida, Zen-ichi; Kawase, Tokuzo; Awaji, Hiroshi; Yoneda, Shigeo
Tetrahedron Letters, 1983 , vol. 24, # 33 p. 3473 - 3476
反应条件
in methanol; water; acetic acid
T=50°C; 4 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/39325 A2, 2006 ;
Location in patent: Page/Page column 45 ;
WO 2006/039325 A2
反应条件
triethylamine in tetrahydrofuran
Ambient temperature;
参考文献
Yoshida, Zen-ichi; Kawase, Tokuzo; Awaji, Hiroshi; Yoneda, Shigeo
Tetrahedron Letters, 1983 , vol. 24, # 33 p. 3473 - 3476
参考文献
Volodarskii, L. B.; Grigor'eva, L. N.; Tikhonov, A. Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 1128 - 1132
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 10 p. 1414 - 1418
反应条件
1: ethane-1,2-dial; 3-amino-5-chloro-1,2,4-thiadiazole in ethanol
T=80°C; 4 h;
2: formaldehyd With phosphoric acid; ammonium chloride in ethanol
参考文献
KALYPSYS, INC.
Patent: WO2007/76460 A2, 2007 ;
Location in patent: Page/Page column 23; 24; 25 ;
WO 2007/076460 A2
反应条件
potassium cyanide; potassium hydroxide; potassium carbonate in water
T=0 - 40°C; 4 h;
参考文献
Courcot, Blandine; Tran, Diem Ngan; Fraisse, Bernard; Bonhomme, Francois; Marsura, Alain; Ghermani, Nour Eddine
Chemistry - A European Journal, 2007 , vol. 13, # 12 p. 3414 - 3423
反应条件
ammonium acetate; acetic acid in water
T=80°C; 24 h;
参考文献
Martinez, Regina; Torregrosa, Rosario; Pastor, Isidro M.; Yus, Miguel
Synthesis (Germany), 2012 , vol. 44, # 16 p. 2630 - 2638
反应条件
1: ethane-1,2-dial With phosphorous pentoxide; water
T=20°C; 0.0833333 h;
2: monomethylthiourea T=20°C; 0.166667 h;
参考文献
Baccolini, Graziano; Boga, Carla; Delpivo, Camilla; Micheletti, Gabriele
Tetrahedron Letters, 2011 , vol. 52, # 14 p. 1713 - 1717
反应条件
triethylamine in ethanol; water
T=50°C; 1 h;
参考文献
Tao, Zhi-Gang; Zhan, Tian-Guang; Zhou, Tian-You; Zhao, Xin; Li, Zhan-Ting
Chinese Chemical Letters, 2013 , vol. 24, # 6 p. 453 - 456
