(3S,4R)-吡咯烷-3,4-二醇合成路线 （共 5 条）
反应条件
cyclohexene; palladium 10 on activated carbon in ethanol 6 h; Heating / reflux;
参考文献
SUNESIS PHARMACEUTICALS, INC.
Patent: WO2005/44817 A1, 2005 ;
Location in patent: Page/Page column 124-125 ;
反应条件
1: With osmium(VIII) oxide; 4-methylmorpholine N-oxide in tetrahydrofuran; water; tert-butyl alcohol T=20°C; 16 h; 2: With hydrogen in methanol T=20°C; 16 h;
参考文献
NOVARTIS AG; FURET, Pascal; GROTZFELD, Robert Martin; JONES, Darryl Brynley; MANLEY, Paul; MARZINZIK, Andreas; PELLE, Xavier Francois Andre; SALEM, Bahaa; SCHOEPFER, Joseph; SPIESER, erich Alois
Patent: WO2013/171640 A1, 2013 ;
Location in patent: Paragraph 00720-00721 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol T=50°C;
参考文献
Defoin, Albert; Pires, Joaquim; Streith, Jacques
Helvetica Chimica Acta, 1991 , vol. 74, # 8 p. 1653 - 1670
反应条件
H6O6Os(2-)*2K(1+); 4-methylmorpholine N-oxide; citric acid in water; tert-butyl alcohol 24 h;
参考文献
Mwangi, Martin T.; Schulz, Michael D.; Bowden, Ned B.
Organic Letters, 2009 , vol. 11, # 1 p. 33 - 36
反应条件
10 palladium on activated carbon; hydrogen T=55°C;
参考文献
Seneviratne, Uthpala; Antsypovich, Sergey; Goggin, Melissa; Dorr, Danae Quirk; Guza, Rebecca; Moser, Adam; Thompson, Carrie; York, Darrin M.; Tretyakova, Natalia
Chemical Research in Toxicology, 2010 , vol. 23, # 1 p. 118 - 133
