(R)-2-(Boc-氨基)-3-(Fmoc-氨基)丙酸合成路线 （共 6 条）
反应条件
pyridine; anhydrous sodium hydrogen carbonate in water; N,N-dimethyl-formamide; acetone
参考文献
Hoffmann-La Roche Inc.
Patent: US6331640 B1, 2001 ;
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; Acylation; 2 h;
参考文献
Yu, Chongxi; Taylor, John W.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 1 p. 161 - 175
反应条件
sodium carbonate in 1,4-dioxane 1.) 1 h, 0 deg C, 2.) 1 h, 25 deg C;
参考文献
Ruan, Fuqiang; Chen, Yanqiu; Itoh, Katsumi; Sasaki, Tomikazu; Hopkins, Paul B.
Journal of Organic Chemistry, 1991 , vol. 56, # 14 p. 4347 - 4354
反应条件
1: 76.5 percent / bis(trifluoroacetoxy)-phenyliodine; N,N-diisopropylethylamine / acetonitrile; H2O / 20 °C 2: 71.2 percent / NaHCO3 / H2O; dioxane / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 1 p. 161 - 175
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: diethylamine / methanol / 20 °C / Inert atmosphere View Scheme
参考文献
Tosatti, Paolo; Horn, Joachim; Campbell, Amanda J.; House, David; Nelson, Adam; Marsden, Stephen P.
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3153 - 3157
反应条件
trifluoroacetic acid in dichloromethane T=50°C; 1 h;
参考文献
Roviello, Giovanni N.; Musumeci, Domenica; Bucci, Enrico M.; Pedone, Carlo
Amino Acids, 2012 , vol. 43, # 6 p. 2537 - 2543
