2,4-二氯-5-硝基-6-甲基嘧啶合成路线 （共 25 条）
反应条件
tetraethylammonium chloride; 2,3-dimethyl aniline; trichlorophosphate in acetonitrile
参考文献
Chen; Adrian; Cushing; DiMaio; Liang; Mayorga; Miao; Peterson; Powers; Spector; Stein; Wright; Xu; Ye; Jaen
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2188 - 2192
反应条件
1: 75 percent / KNO3; H2SO4 2: 60 percent / POCl3; PhNEt2 / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 15 p. 2497 - 2500
参考文献
Journal of the Chemical Society, , p. 1004,1015
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, vol. 24, p. 84
反应条件
T=150 - 160°C; im Rohr;
参考文献
Chemische Berichte, , vol. 34, p. 1242
反应条件
1: 79 percent / NaOAc; AcOH / ethanol; H2O 2: NH3 / CHCl3 / Heating View Scheme
参考文献
Chen; Adrian; Cushing; DiMaio; Liang; Mayorga; Miao; Peterson; Powers; Spector; Stein; Wright; Xu; Ye; Jaen
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2188 - 2192
反应条件
1: in methanol T=-10°C; 0.166667 h; 2: With acetic acid in methanol
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/99688 A2, 2005 ;
Location in patent: Page/Page column 145-146 ;
WO 2005/099688 A2
反应条件
in methanol T=0°C; 0.25 h;
参考文献
Cupps, Thomas L.; Wise, Dean S.; Townsend, Leroy B.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1060 - 1064
反应条件
1: palladium/charcoal; aq.-ethanolic HCl / Hydrogenation 2: N2H4+H2O; palladium/charcoal; ethanolic KOH View Scheme
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; SKELTON, Nicholas; GRADL, Stefan; BLAKE, James F.; GRAHAM, James M.; GUNAWARDANA, Indrani W.; HENTEMANN, Martin; MARLOW, Allison L.; TANG, Tony P.
Patent: WO2013/78254 A1, 2013 ;
Location in patent: Paragraph 00491 ;
参考文献
Gabriel; Colman
Chemische Berichte, 1901 , vol. 34, p. 1242
参考文献
Gabriel; Colman
Chemische Berichte, 1901 , vol. 34, p. 1242
