ammonia in tetrahydrofuran; water 0.25 h;

1: ammonium hydroxide / 40 °C / |Large scale 2: hydrogen / water; ethanol; ethyl acetate / 1.67 h / 40 °C / 2828.7 Torr / |Cooling; |Large scale 3: hydrogenchloride / ethyl acetate / 30 °C / |Cooling; |Large scale 4: 1-methyl-pyrrolidin-2-one / 30 - 50 °C / |Large scale 5: acetic acid / water / 4 h / |Inert atmosphere; |Reflux; |Large scale View Scheme

1: conc. aq. NH3 / tetrahydrofuran; dimethylformamide 2: H2 / 10percent Pd/C / methanol / 760.05 Torr View Scheme