7-氯喹啉-2,4(1氢,3氢)-二酮合成路线 （共 20 条）
反应条件
sodium hydroxide in water T=28 - 60°C; pH=6.5 - 6.9; 5.5 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6344559 B1, 2002 ;
Location in patent: Page column 4 ;
参考文献
Journal of the Chemical Society, , p. 1759,1765
反应条件
1: 97.9 percent / POCl3, N,N-dimethylaniline / Heating 2: 89.4 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C 3: 66.4 percent / butan-1-ol / 14 h / 95 °C View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 90.4 percent / fuming nitric acid, conc. sulfuric acid / 4 h / 60 - 80 °C 2: 97 percent / POCl3, N,N-dimethylaniline / Heating 3: 82 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C 4: 59.7 percent / butan-1-ol / 14 h / 95 °C View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 97.9 percent / POCl3, N,N-dimethylaniline / Heating 2: 89.4 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: POCl3; N,N-dimethylaniline / 16 h / Heating 2: aq. NaOH / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Ram, Vishnu Ji; Farhanullah; Tripathi, Brajendra K.; Srivastava, Arvind K.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 11 p. 2439 - 2444
反应条件
N,N-dimethyl-aniline; trichlorophosphate Heating;
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
1: potassium carbonate / N,N-dimethyl-formamide
2: potassium carbonate / acetone / 5 h / 20 °C / |Reflux; |Large scale
View Scheme
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
sulfuric acid; nitric acid
0.166667 h; 1.) -10 deg C, 2.) steam bath;
参考文献
Schneller, Stewart W.; Christ, William J.
Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1699 - 1702
