N-羟基-3-[1-(苯基硫代)甲基-1H-1,2,3-三氮唑-4-基]苯甲酰胺合成路线 （共 6 条）
反应条件
copper(II) sulfate; sodium L-ascorbate; TBTA in methanol; water T=20°C; 24 h; Combinatorial reaction / High throughput screening (HTS);
参考文献
Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; Iida, Shinsuke; Ueda, Ryuzo; Shirahige, Katsuhiko; Miyata, Naoki
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9562 - 9575
反应条件
1: sulfuric acid / 30 h / |Reflux 2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 18 h / 20 °C 3: sodium hydroxide; water / methanol / 5 h / 0 - 20 °C 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C 5: toluene-4-sulfonic acid / methanol / 12 h / 20 °C 6: copper(II) sulfate; TBTA; sodium L-ascorbate / water; methanol / 24 h / 20 °C / |Combinatorial reaction / High throughput screening (HTS) View Scheme
参考文献
Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; Iida, Shinsuke; Ueda, Ryuzo; Shirahige, Katsuhiko; Miyata, Naoki
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9562 - 9575
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 18 h / 20 °C 2: sodium hydroxide; water / methanol / 5 h / 0 - 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C 4: toluene-4-sulfonic acid / methanol / 12 h / 20 °C 5: copper(II) sulfate; TBTA; sodium L-ascorbate / water; methanol / 24 h / 20 °C / |Combinatorial reaction / High throughput screening (HTS) View Scheme
参考文献
Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; Iida, Shinsuke; Ueda, Ryuzo; Shirahige, Katsuhiko; Miyata, Naoki
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9562 - 9575
反应条件
1: sodium hydroxide; water / methanol / 5 h / 0 - 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C 3: toluene-4-sulfonic acid / methanol / 12 h / 20 °C 4: copper(II) sulfate; TBTA; sodium L-ascorbate / water; methanol / 24 h / 20 °C / |Combinatorial reaction / High throughput screening (HTS) View Scheme
参考文献
Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; Iida, Shinsuke; Ueda, Ryuzo; Shirahige, Katsuhiko; Miyata, Naoki
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9562 - 9575
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C 2: toluene-4-sulfonic acid / methanol / 12 h / 20 °C 3: copper(II) sulfate; TBTA; sodium L-ascorbate / water; methanol / 24 h / 20 °C / |Combinatorial reaction / High throughput screening (HTS) View Scheme
参考文献
Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; Iida, Shinsuke; Ueda, Ryuzo; Shirahige, Katsuhiko; Miyata, Naoki
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9562 - 9575
反应条件
1: toluene-4-sulfonic acid / methanol / 12 h / 20 °C 2: copper(II) sulfate; TBTA; sodium L-ascorbate / water; methanol / 24 h / 20 °C / |Combinatorial reaction / High throughput screening (HTS) View Scheme
参考文献
Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; Iida, Shinsuke; Ueda, Ryuzo; Shirahige, Katsuhiko; Miyata, Naoki
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9562 - 9575
