N-Boc-3,4-二氢-2H-吡啶合成路线 （共 23 条）
反应条件
1: With lithium triethylborohydride in tetrahydrofuran; toluene T=-70°C; 0.5 h; 2: With 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride in tetrahydrofuran; toluene T=-70 - 20°C; 2 h;
参考文献
Yu, Jurong; Truc, Vu; Riebel, Peter; Hierl, Elizabeth; Mudryk, Boguslaw
Tetrahedron Letters, 2005 , vol. 46, # 23 p. 4011 - 4013
反应条件
potassium carbonate; tetrabutyl-ammonium chloride in water T=20 - 101°C; Heating / reflux;
参考文献
WO2005/92832 A1, ;
Page/Page column 44-46 ;
反应条件
caesium carbonate in dimethyl sulfoxide T=120°C; 3 h;
参考文献
Tetrahedron, , vol. 67, # 7 p. 1485 - 1500
反应条件
Schwartz's reagent in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 52, # 51 p. 6880 - 6882
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide T=160 - 180°C;
参考文献
Dieter, R. Karl; Sharma, Ram R.
Journal of Organic Chemistry, 1996 , vol. 61, # 12 p. 4180 - 4184
反应条件
1: With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether T=-78°C; 3 h; 2: With zinc(II) chloride in tetrahydrofuran; diethyl ether 0.666667 h; regioselective reactionFurther stages;
参考文献
Coldham, Iain; Leonori, Daniele
Journal of Organic Chemistry, 2010 , vol. 75, # 12 p. 4069 - 4077
反应条件
pyridine; Dess-Martin periodane in dichloromethane T=20°C; 0.5 h;
参考文献
Yu, Chengzhi; Hu, Longqin
Tetrahedron Letters, 2001 , vol. 42, # 31 p. 5167 - 5170
反应条件
trimethylsilylazide; 2-iodosylbenzoic acid in dichloromethane Heating;
参考文献
Journal of the American Chemical Society, , vol. 116, # 10 p. 4501 - 4502
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine in 1,4-dioxane T=50°C; 2 h;
参考文献
Occhiato, Ernesto G.; Lo Galbo, Fabrizio; Guarna, Antonio
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7324 - 7330
反应条件
1: 79 percent / DMAP / acetonitrile 2: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3: 86 percent / p-TsOH / toluene / 0.33 h View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
