3-(2-甲氧基吡啶-3-基)丙烯酸合成路线 （共 4 条）
反应条件
potassium hydroxide in methanol; water T=60°C; 16 h; Inert atmosphere;
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
反应条件
piperidine; pyridine 3 h; Heating;
参考文献
Trecourt, Francois; Marsais, Francis; Guengoer, Timur; Queguiner, Guy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 9 p. 2409 - 2415
反应条件
1: 1) butyllithium, di-isopropylamide / 1) THF, hexane, 0 deg C, 1 h 2) THF, -70 deg C, 3 h 2: 1) MeOH, reflux, 5 h 2) hydrolysis 3: 78 percent / piperidine, pyridine / 3 h / Heating View Scheme
参考文献
Trecourt, Francois; Marsais, Francis; Guengoer, Timur; Queguiner, Guy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 9 p. 2409 - 2415
反应条件
1: 1) MeOH, reflux, 5 h 2) hydrolysis 2: 78 percent / piperidine, pyridine / 3 h / Heating View Scheme
参考文献
Trecourt, Francois; Marsais, Francis; Guengoer, Timur; Queguiner, Guy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 9 p. 2409 - 2415
