1-[(5-羟基-4-甲氧基-1-环己-2-烯基)甲基]-6-甲氧基-7-异喹啉醇合成路线 （共 20 条）
反应条件
2,3-dihydroxybutanedioic acid in water 144 h; biosynthesis in Cocculus laurifolius DC (Menispermaceae);
参考文献
Bhakuni, Dewan S.; Jain, Sudha; Gupta, Sandeep
Tetrahedron, 1986 , vol. 42, # 2 p. 675 - 680
反应条件
1: 1.) 10percent Pd/C / 1.) toluene, reflux, 30 min., 2.) toluene, reflux, 4.75 h. 2: 70 percent / methanol; diethyl ether / 1.33 h View Scheme
参考文献
Buchs; Brossi
Helvetica Chimica Acta, 1981 , vol. 64, # 3 p. 681 - 686
反应条件
hydrogen; palladium on activated charcoal in acetic acid
1 h;
参考文献
Buchs; Brossi
Helvetica Chimica Acta, 1981 , vol. 64, # 3 p. 681 - 686
反应条件
1: 81 percent / acetone / 24 h / 60 °C
2: 82 percent / NaBH4 / methanol / 0.33 h / 1.) ice-cooling, 2.) room temp.
3: 86 percent / H2 / 10percent Pd/C / acetic acid / 1 h
View Scheme
参考文献
Buchs; Brossi
Helvetica Chimica Acta, 1981 , vol. 64, # 3 p. 681 - 686
反应条件
1: 90.4 percent / Heating
2: POCl3 / acetonitrile / Heating
3: NaBH4
View Scheme
参考文献
Rice; Brossi
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 592 - 601
反应条件
1: 1.) BH3, HCl; 2.) aqueous NH3
2: 90.4 percent / Heating
3: POCl3 / acetonitrile / Heating
4: NaBH4
View Scheme
参考文献
Rice; Brossi
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 592 - 601
反应条件
1: POCl3 / acetonitrile / Heating
2: NaBH4
View Scheme
参考文献
Rice; Brossi
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 592 - 601
反应条件
1: 90.4 percent / Heating
2: POCl3 / acetonitrile / Heating
3: NaBH4
View Scheme
参考文献
Rice; Brossi
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 592 - 601
反应条件
1: sodium cyanoborohydride / methanol / 1 h / 20 °C / pH Ca. 3
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / |Reflux
3: water / benzene / 120 °C
4: zinc; acetic acid / water / 5 h / 20 °C
5: boron trichloride / dichloromethane / -10 - 20 °C
View Scheme
参考文献
Dion, Isabelle; Vincent-Rocan, Jean-Francois; Zhang, Lei; Cebrowski, Pamela H.; Lebrun, Marie-Eve; Pfeiffer, Jennifer Y.; Bedard, Anne-Catherine; Beauchemin, Andre M.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12735 - 12749
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / |Reflux
2: water / benzene / 120 °C
3: zinc; acetic acid / water / 5 h / 20 °C
4: boron trichloride / dichloromethane / -10 - 20 °C
View Scheme
参考文献
Dion, Isabelle; Vincent-Rocan, Jean-Francois; Zhang, Lei; Cebrowski, Pamela H.; Lebrun, Marie-Eve; Pfeiffer, Jennifer Y.; Bedard, Anne-Catherine; Beauchemin, Andre M.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12735 - 12749
