1: 96 percent / HCl / H2O / 43 h / 55 °C 2: 93 percent / hydrogen / Pd/C / methanol / 3 h View Scheme

1: 47 percent / triphenylphosphine; diisopropyl azodicarboxylate; hydrazoic acid / tetrahydrofuran; toluene / 0.02 h / cooling 2: 48 percent / Rhodococcus erythropolis AJ270; potassium phosphate buffer / H2O / 3.5 h / pH 7.0 3: 96 percent / HCl / H2O / 43 h / 55 °C 4: 93 percent / hydrogen / Pd/C / methanol / 3 h View Scheme

1: 98 percent / NaBH4 / propan-2-ol / 20 °C 2: 47 percent / triphenylphosphine; diisopropyl azodicarboxylate; hydrazoic acid / tetrahydrofuran; toluene / 0.02 h / cooling 3: 48 percent / Rhodococcus erythropolis AJ270; potassium phosphate buffer / H2O / 3.5 h / pH 7.0 4: 96 percent / HCl / H2O / 43 h / 55 °C 5: 93 percent / hydrogen / Pd/C / methanol / 3 h View Scheme

hydrogenchloride; water T=90°C; 12 h;

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -20 °C 1.2: 3.75 h / -20 - 20 °C 2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C 2.2: 12 h / -78 °C 3.1: hydrogen; palladium 10 on activated carbon / ethyl acetate / 16 h / 760.05 Torr 4.1: triethylamine; diphenyl phosphoryl azide / 3 h / |Reflux 5.1: lithium hydroxide hydrate; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 0 °C 6.1: hydrogen; palladium 10 on activated carbon / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

1: 93 percent / H2O2, LiOH*H2O / H2O; tetrahydrofuran / 1 h / 0 °C 2: 71 percent / aq. HCl / acetic acid / 48 h / Heating View Scheme

potassium phosphate; water T=37°C; pH=7.2; 264 h; Enzymatic reaction;