1-甲氧基-1,2-丙二烯合成路线 （共 58 条）
反应条件
Ti(N(CH3)2)2(C6H5CONC6H3(CH(CH3)2)2)2
T=110°C; 24 h; Inert atmosphere;
参考文献
Ayinla, Rashidat O.; Schafer, Laurel L.
Dalton Transactions, 2011 , vol. 40, # 30 p. 7769 - 7776
反应条件
n-butyllithium in tetrahydrofuran
1.) -23 deg C, 1 h, 2.) -20 deg C;
参考文献
Kucerovy, Andrew; Neuenschwander, Kent; Weinreb, Steven M.
Synthetic Communications, 1983 , vol. 13, # 11 p. 875 - 880
反应条件
n-butyllithium in tetrahydrofuran
1.) -23 deg C, 1 h, 2.) -20 deg C;
参考文献
Kucerovy, Andrew; Neuenschwander, Kent; Weinreb, Steven M.
Synthetic Communications, 1983 , vol. 13, # 11 p. 875 - 880
反应条件
n-butyllithium in tetrahydrofuran
1.) -23 deg C, 1 h, 2.) -20 deg C;
参考文献
Kucerovy, Andrew; Neuenschwander, Kent; Weinreb, Steven M.
Synthetic Communications, 1983 , vol. 13, # 11 p. 875 - 880
反应条件
n-butyllithium in tetrahydrofuran
1.) -23 deg C, 1 h, 2.) -20 deg C;
参考文献
Kucerovy, Andrew; Neuenschwander, Kent; Weinreb, Steven M.
Synthetic Communications, 1983 , vol. 13, # 11 p. 875 - 880
反应条件
1: 1-methoxy-allene With n-butyllithium in diethyl ether
T=-40°C; Inert atmosphere;
2: 2,2-dimethyl-1-propanenitrile T=-78°C; Inert atmosphere;
3: trifluoroacetic acid Further stages;
参考文献
Lechel, Tilman; Podolan, Gabriel; Brusilowskij, Boris; Schalley, Christoph A.; Reissig, Hans-Ulrich
European Journal of Organic Chemistry, 2012 , # 29 p. 5685 - 5692,8
反应条件
1: 1-methoxy-allene With n-butyllithium in diethyl ether
T=-40°C; Inert atmosphere;
2: 2,2-dimethyl-1-propanenitrile T=-78°C; Inert atmosphere;
3: trifluoroacetic acid T=-78 - 20°C; 4 h;
参考文献
Lechel, Tilman; Podolan, Gabriel; Brusilowskij, Boris; Schalley, Christoph A.; Reissig, Hans-Ulrich
European Journal of Organic Chemistry, 2012 , # 29 p. 5685 - 5692,8
反应条件
1: n-butyllithium; 1-methoxy-allene With copper(l) iodide in diethyl ether; hexane
T=-40°C; 0.5 h;
2: allyl bromide in tetrahydrofuran; diethyl ether; hexane
T=-30°C; 1 h;
参考文献
Chinkov, Nicka; Majumdar, Swapan; Marek, Ilan
Journal of the American Chemical Society, 2002 , vol. 124, # 35 p. 10282 - 10283
反应条件
1: 1-methoxy-allene; n-Bu2CuLi in diethyl ether; hexane
T=-40°C; 0.5 h;
2: allyl bromide in tetrahydrofuran; diethyl ether; hexane
T=-65 - -40°C;
参考文献
Chinkov, Nicka; Majumdar, Swapan; Marek, Ilan
Journal of the American Chemical Society, 2003 , vol. 125, # 43 p. 13258 - 13264
反应条件
n-butyllithium
1) -25 deg C, 20 min, THF, 2) -25 deg C, 4 h; Multistep reaction;
参考文献
Hoffmann, Reinhard W.; Metternich, Rainer
Liebigs Annalen der Chemie, 1985 , # 12 p. 2390 - 2402
