1-(2-溴乙基)-1H-吡唑-3,5-二羧酸二乙酯合成路线 （共 2 条）
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; 1.5 h;
参考文献
WEINGARTEN, M., David; MENG, Charles, Q.; SIKORSKI, James, A.; WORSENCROFT, Kimberly, J.; YE, Zhihong; SIMPSON, Jr., Jacob, E.; NI, Liming; CLARK, Cynthia
Patent: WO2012/135669 A1, 2012 ;
Location in patent: Page/Page column 244-245 ;
反应条件
sodium ethanolate 1.) ethanol, RT, 20 min. 2.) ethanol, reflux, 24 h; Yield given. Multistep reaction;
参考文献
Bagley; Thomas; Rudo; Spencer; Doorley; Ossipov; Jerussi; Benvenga; Spaulding
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 827 - 841
