(4-硝基吡啶-2-基)乙酸甲酯合成路线 （共 8 条）
反应条件
acetic anhydride; sodium hydrogencarbonate in ethanol; water
参考文献
KABUSHIKI KAISHA NARD KENKYUSHO
Patent: EP1455189 A1, 2004 ;
反应条件
in ethanol T=80 - 120°C; 0.55 h;
参考文献
KuDOS Pharmaceuticals Limited
Patent: US2007/93489 A1, 2007 ;
Location in patent: Page/Page column 20 ;
US 20070093489 A1
参考文献
Chen, Hongfeng; Sweet, James A.; Lam, Kin-Chung; Rheingold, Arnold L.; McGrath, Dominic V.
Tetrahedron Asymmetry, 2009 , vol. 20, # 14 p. 1672 - 1682
反应条件
1: 83.9 percent / H2SO4; HNO3 / 2 h / 110 - 115 °C 2: 0.5 h / 110 - 120 °C View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 1 mol/l aq. NaOH / methanol / 0.75 h / 20 °C 2: SOCl2 / CH2Cl2 / Heating View Scheme
参考文献
Tamura; Urano; Kikuchi; Higuchi; Hirobe; Nagano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1514 - 1518
反应条件
water; sodium hydroxide in methanol 1.5 h; Inert atmosphereReflux;
参考文献
Chen, Hongfeng; Sweet, James A.; Lam, Kin-Chung; Rheingold, Arnold L.; McGrath, Dominic V.
Tetrahedron Asymmetry, 2009 , vol. 20, # 14 p. 1672 - 1682
反应条件
1: 74 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature 2: 66 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
