(3-三氟甲基吡啶-2-基)甲醇合成路线 （共 5 条）
反应条件
sodium hydroxide in methanol 1.5 h; Ambient temperature;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 2) m-chloroperbenzoic acid / 1) Pd(PPh3)4 / 1) dioxane, hexane, reflux, 2) CHCl3, rt 2: 54 percent / Heating 3: 76 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 54 percent / Heating 2: 76 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide 1.5 h; Ambient temperature;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
参考文献
XENON PHARMACEUTICALS INC.; CADIEUX, Jean-Jacques; CHAFEEV, Mikhail; CHOWDHURY, Sultan; DOUGLAS, Amy Frances; FU, Jianmin; LANGILLE, Jonathan; SUN, Shaoyi; WOOD, Mark
Patent: WO2010/78307 A1, 2010 ;
Location in patent: Page/Page column 57-58 ;
WO 2010/078307 A1
