2-氟-3-(羟甲基)吡啶合成路线 （共 8 条）
反应条件
lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: With sodium tetrahydroborate; ethanol T=0 - 20°C; 2 h; Inert atmosphere; 2: With water Inert atmosphere;
参考文献
WO2010/132999 A1, ;
Page/Page column 98 ;
反应条件
potassium carbonate in water Hydrolysis; Heating;
参考文献
Journal of Organic Chemistry, , vol. 65, # 23 p. 7718 - 7722
反应条件
1: 36 percent / NaNO2, HBF4 / 0 deg C to rt 2: 30 percent / KMnO4 / H2O / Heating 3: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 30 percent / KMnO4 / H2O / Heating 2: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide 1.5 h; Ambient temperature;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; Inert atmosphereCooling with ice;
参考文献
GLAXO GROUP LIMITED; Castro Pichel, Julia; Fernandez Menendez, Raquel; Fernandez Velando, Esther Pilar; Gonzalez Del Valle, Silvia; Mallo-Rubio, Araceli
Patent: US2013/203802 A1, 2013 ;
Location in patent: Paragraph 0250; 0251 ;
反应条件
thionyl chloride Chlorination; 0.916667 h;
参考文献
Pesti; Huhn; Yin; Xing; Fortunak; Earl
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7718 - 7722
