(2-三氟甲基-吡啶-3-基)-甲醇合成路线 （共 8 条）
反应条件
lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
diisobutylaluminium hydride in tetrahydrofuran 18 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 12 p. 2146 - 2163
反应条件
1: 1.) NaH, H2O / 1.) DMF, 60 deg C, 45 min, 2.) DMF, 60 deg C, 1 h 2: DIBAL / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 12 p. 2146 - 2163
反应条件
1: 88 percent / NaNO2, Br2, 48percent HBr / 5 °C 2: 48 percent / Cu, HMPA / 4 h / 112 - 130 °C / autoclave 3: 34 percent / KMnO4 / H2O / Heating 4: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 48 percent / Cu, HMPA / 4 h / 112 - 130 °C / autoclave 2: 34 percent / KMnO4 / H2O / Heating 3: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 34 percent / KMnO4 / H2O / Heating 2: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide 1.5 h; Ambient temperature;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
phosphorus tribromide in dichloromethane T=0 - 20°C; 1.5 h;
参考文献
CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita
Patent: WO2010/132999 A1, 2010 ;
Location in patent: Page/Page column 210 ;
