(5-(三氟甲基)吡啶-3-基)甲醇合成路线 （共 3 条）
反应条件
lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min; Yield given. Multistep reaction;
参考文献
GILEAD SCIENCES, INC.; BABAOGLU, Kerim; BJORNSON, Kyla, L.; HRVATIN, Paul; LANSDON, Eric; LINK, John, O.; LIU, Hongtao; MCFADDEN, Ryan; MITCHELL, Michael, L.; QI, Yingmei; ROETHLE, Paul, A.; XU, Lianhong
Patent: WO2013/103724 A1, 2013 ;
Location in patent: Page/Page column 108 ;
反应条件
1: 2) KMnO4 / 1) Pd(PPh3)4 / 1) dioxane, hexane, reflux, 2) H2O, reflux 2: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide
1.5 h; Ambient temperature;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
