2,2,2-trifluoroethanol; tetrabutyl ammonium fluoride in tetrahydrofuran T=-78 - 20°C; 0.5 h;

1: 95 percent / K2CO3 / acetone / 48 h / Heating 2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h 3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h 4: 2,2,2-trifluoroethanol, tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / -78 - 20 °C View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h 2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h 3: 2,2,2-trifluoroethanol, tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / -78 - 20 °C View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h 2: 2,2,2-trifluoroethanol, tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / -78 - 20 °C View Scheme

in tetrahydrofuran; methanol