(S,S)-(-)-2,2'-异亚丙基双(4-叔丁基-2-恶唑啉)合成路线 （共 11 条）
反应条件
1: t-Bu2-Box With n-butyllithium; N,N,N',N,-tetramethylethylenediamine; diisopropylamine in tetrahydrofuran; hexane T=-75 - -20°C; Metallation; 2: methyl iodide in tetrahydrofuran; hexane T=-68 - 20°C; Alkylation; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 65, # 18 p. 5875 - 5878
反应条件
zinc trifluoromethanesulfonate in toluene 72 h; Heating;
参考文献
Synlett, , # 15 art. no. G13005ST, p. 2321 - 2324
反应条件
zinc trifluoromethanesulfonate in toluene T=110°C; 168 h;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2270 - 2275
反应条件
1: 88 percent / triethylamine / CH2Cl2 / 0.75 h / 0 - 20 °C 2: 82 percent / 4-(dimethylamino)pyridine, triethylamine / CH2Cl2 / 27 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 13 p. 4541 - 4544
反应条件
1: 90 percent / oxalyl chloride / dimethylformamide / 18 h / 25 °C 2: 88 percent / triethylamine / CH2Cl2 / 0.75 h / 0 - 20 °C 3: 82 percent / 4-(dimethylamino)pyridine, triethylamine / CH2Cl2 / 27 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 13 p. 4541 - 4544
反应条件
1: α,α-dimethylmalononitrile; (S)-2-amino-3,3-dimethyl-1-butanol With zinc diacetate in toluene 24 h; Heating; 2: (S)-2-aminopropanol With zinc trifluoromethanesulfonate in toluene 72 h; Heating;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2270 - 2275
反应条件
1: α,α-dimethylmalononitrile; (S)-2-amino-3,3-dimethyl-1-butanol With zinc diacetate in toluene 24 h; Heating; 2: (R)-2-amino-3-benzyloxy-1-propanol With zinc trifluoromethanesulfonate in toluene 72 h; Heating;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2270 - 2275
反应条件
1: 1.756 g / zinc acetate / toluene / 21 h / 110 °C 2: zinc triflate / toluene / 168 h / 110 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2270 - 2275
反应条件
1: 1.756 g / zinc acetate / toluene / 21 h / 110 °C 2: zinc triflate / toluene / 168 h / 110 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2270 - 2275
反应条件
1: α,α-dimethylmalononitrile; (S)-2-amino-3,3-dimethyl-1-butanol With zinc diacetate in toluene 24 h; Heating; 2: (S)-(-)-2-amino-3-phenyl-1-propanol With zinc trifluoromethanesulfonate in toluene 72 h; Heating;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2270 - 2275
