(S)-(-)-1-苄基-3-(叔丁氧羰基氨基)吡咯烷合成路线 （共 9 条）
反应条件
1: (3S)-(+)-1-Benzyl-3-aminopyrrolidine With sodium hydroxide in water T=50 - 60°C; pH=11; 2: di-tert-butyl dicarbonate in water pH=11; 3 h;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1640364 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: 96.7 percent / Et3N / tetrahydrofuran / 4 h / -10 - 0 °C 2: NaN3 / dimethylformamide / 80 °C 3: LiAlH4 / tetrahydrofuran / 6 h / Heating 4: 77 percent / CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1815 - 1826
反应条件
1: LiAlH4 / tetrahydrofuran / 6 h / Heating 2: 77 percent / CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1815 - 1826
反应条件
1: NaN3 / dimethylformamide / 80 °C 2: LiAlH4 / tetrahydrofuran / 6 h / Heating 3: 77 percent / CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1815 - 1826
反应条件
1: NaBH4, CaCl2 / ethanol / 2 h / 0 °C 2: Et3N / CH2Cl2 / 1 h / -10 - 0 °C 3: CH2Cl2 / 24 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 28, # 21 p. 3919 - 3926
反应条件
1: Et3N / CH2Cl2 / 1 h / -10 - 0 °C 2: CH2Cl2 / 24 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 28, # 21 p. 3919 - 3926
反应条件
in dichloromethane 24 h; Heating; Yield given;
参考文献
Synthetic Communications, , vol. 28, # 21 p. 3919 - 3926
反应条件
1: CF3CO2H / CH2Cl2 2: pyridine View Scheme
参考文献
Synthetic Communications, , vol. 28, # 21 p. 3919 - 3926
反应条件
10 palladium on carbon; hydrogen in methanol T=20°C; 24 h;
参考文献
Tetrahedron Asymmetry, , vol. 21, # 11-12 p. 1511 - 1521
