(3S,5Z,8Xi,14Xi,22E)-3-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-9,10-开环麦角甾-5,10,22-三烯-7,8-二醇合成路线 （共 3 条）
反应条件
1H-imidazole; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; Etherification;
参考文献
Blakemore; Kocienski; Marzcak; Wicha
Synthesis, 1999 , # 7 p. 1209 - 1215
反应条件
1: KMnO4 View Scheme
参考文献
Polish Journal of Chemistry, , vol. 73, # 7 p. 1209 - 1217
反应条件
1.1: pyridine; Pb(OAc)4 / CH2Cl2 / 0.25 h / 0 °C 1.2: 83 percent / CeCl3*7H2O; NaBH4 / methanol / 0.25 h / 0 °C 2.1: 81 percent / Amberlite<*> IR-118 ion-exchange resin; Na; EtOH / diethyl ether / 2.5 h / 0 °C 3.1: 72 percent / PPh3; diisopropyl azodicarboxylate / tetrahydrofuran / 25 h / 0 - 20 °C 4.1: 73 percent / H2O2 / (NH4)6Mo7O24*4H2O / aq. ethanol / 240 h / 20 °C 5.1: NaHMDS / diethyl ether; tetrahydrofuran / 1 h / -78 °C 5.2: Dess-Martin periodinane / CH2Cl2 / 0.5 h / 20 °C 5.3: diethyl ether; tetrahydrofuran / -100 - 20 °C 6.1: Bu4NF*3H2O / tetrahydrofuran / 20 °C / overnight View Scheme
参考文献
Blakemore; Kocienski; Marzcak; Wicha
Synthesis, 1999 , # 7 p. 1209 - 1215
