2-[2-(4-氯苯基)乙氧基]腺苷合成路线 （共 7 条）
反应条件
triethylamine tris(hydrogen fluoride) in methanol T=50°C; 18 h; Product distribution / selectivity;
参考文献
KING PHARMACEUTICALS RESEARCH and DEVELOPMENT, INC.
Patent: WO2005/33121 A2, 2005 ;
Location in patent: Page/Page column 31-32 ;
反应条件
sodium hydride in methanol T=50°C; 20 h; Product distribution / selectivity;
参考文献
KING PHARMACEUTICALS RESEARCH and DEVELOPMENT, INC.
Patent: WO2005/33121 A2, 2005 ;
Location in patent: Page/Page column 18-19 ;
反应条件
ethanol; ammonia T=-50 - 110°C; 5 - 24 h; Product distribution / selectivity;
参考文献
Moorman, Allan R.
Patent: US2003/199686 A1, 2003 ;
Location in patent: Page/Page column 5-7 ;
反应条件
sodium hydride T=50°C; 48 h; Product distribution / selectivity;
参考文献
KING PHARMACEUTICALS RESEARCH and DEVELOPMENT, INC.
Patent: WO2005/33121 A2, 2005 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1: 1.) n-BuLi / 1.) 1,2-dimethoxyethane, 10 deg C, 15 min, 2.) 1,2-dimethoxyethane, reflux, 5 days 2: acetic acid, formic acid / H2O / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 4 p. 1340 - 1344
反应条件
1: 1.) n-BuLi / 1.) 1,2-dimethoxyethane, 10 deg C, 15 min, 2.) 1,2-dimethoxyethane, reflux, 5 days 2: acetic acid, formic acid / H2O / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 4 p. 1340 - 1344
反应条件
ammonium fluoride in methanol 18 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2005/33121 A2, ;
Page/Page column 28 ;
