alpha-酮戊二酸二甲酯合成路线 （共 32 条）
反应条件
1: With 9-methoxy-10,11-dihydrocinchonidine; hydrogen; 5percent Pt/Al2O3 in acetic acid T=20°C; Catalytic hydrogenation; P=750.075 Torr; 2: With toluene-4-sulfonic acid in acetic acid Cyclization; Further stages. Title compound not separated from byproducts.;
参考文献
Balazsik, Katalin; Szoeri, Kornel; Felfoeldi, Karoly; Toeroek, Bela; Bartok, Mihaly
Chemical Communications, 2000 , # 7 p. 555 - 556
反应条件
Mucor rouxii freeze-dried yeast-like cells in hexane; water T=28°C; 24 h;
参考文献
Drioli, Sara; Nitti, Patrizia; Pitacco, Giuliana; Tossut, Laura; Valentin, Ennio
Tetrahedron Asymmetry, 1999 , vol. 10, # 14 p. 2713 - 2728
反应条件
anhydrous magnesium perchlorate; 4R,9R-Me2PNPH in acetonitrile Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ohno, Atsuyoshi; Yasuma, Tsuneo; Nakamura, Kaoru; Oka, Shinzaburo
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 9 p. 2905 - 2906
反应条件
1: With 9-methoxy-10,11-dihydrocinchonidine; hydrogen; 5percent Pt/Al2O3 in acetic acid T=20°C; Catalytic hydrogenation; P=750.075 Torr; 2: With toluene-4-sulfonic acid in acetic acid Cyclization; Further stages. Title compound not separated from byproducts.;
参考文献
Balazsik, Katalin; Szoeri, Kornel; Felfoeldi, Karoly; Toeroek, Bela; Bartok, Mihaly
Chemical Communications, 2000 , # 7 p. 555 - 556
反应条件
1: 65 percent / aq. NaBH4 2: 55 percent / p-toluenesulfonic acid / toluene / Heating View Scheme
参考文献
Drioli, Sara; Nitti, Patrizia; Pitacco, Giuliana; Tossut, Laura; Valentin, Ennio
Tetrahedron Asymmetry, 1999 , vol. 10, # 14 p. 2713 - 2728
反应条件
anhydrous magnesium perchlorate; 4R,9R-Me2PNPH in acetonitrile Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ohno, Atsuyoshi; Yasuma, Tsuneo; Nakamura, Kaoru; Oka, Shinzaburo
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 9 p. 2905 - 2906
反应条件
1.1: Br2 / CH2Cl2 / 3 h / Heating 1.2: 3.6 mmol / Et3N / diethyl ether / 0.5 h 2.1: 11 percent / toluenesulfonic acid / CH2Cl2 / 24 h / Heating 3.1: 79 percent / aq. OH- / tetrahydrofuran View Scheme
参考文献
Carrigan, Christina N.; Bartlett, Richard D.; Esslinger, C. Sean; Cybulski, Kimberly A.; Tongcharoensirikul, Pakamas; Bridges, Richard J.; Thompson, Charles M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2260 - 2276
反应条件
1: Br2 / CH2Cl2 / Heating 2: Et3N / diethyl ether / 20 h / 25 °C 3: CH2Cl2 / 7 h / 25 °C 4: dry hydrogen chloride / CH2Cl2 / 10 h 5: 60 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.17 h / 0 °C 6: 92 percent / p-tuluenesulfonic acid / methanol / 4 h / Heating 7: 98 percent / 0.5 M K2CO3 / H2O / 4 h / 85 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 103, p. 5599
反应条件
1.1: Br2 / CH2Cl2 / 3 h / Heating 1.2: 3.6 mmol / Et3N / diethyl ether / 0.5 h 2.1: 16 percent / toluenesulfonic acid / CH2Cl2 / 24 h / Heating 3.1: 81 percent / aq. OH- / tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 11 p. 2260 - 2276
反应条件
in methanol T=60°C; Pictet-Spengler reaction;
参考文献
Fokas, Demosthenes; Wang, Zhimin
Synthetic Communications, 2008 , vol. 38, # 21 p. 3816 - 3822
