3-二甲基氨基-1-(2-噻吩基)-1-丙酮合成路线 （共 20 条）
反应条件
sodium hydroxide in water T=20°C;
参考文献
EP1857451 A1, ;
Page/Page column 4 ;
反应条件
hydrogenchloride in ethanol Mannich reaction; Heating;
参考文献
Lewis, David; Zhang, Ying; Prisinzano, Thomas; Dersch, Christina M.; Rothman, Richard B.; Jacobson, Arthur E.; Rice, Kenner C.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1385 - 1389
反应条件
1: ethanol; water / 8 h / pH 3 - 4 / Reflux 2: sodium hydroxide / water / pH 10 View Scheme
反应条件
hydrogenchloride; acetyl chloride in ethylene glycol dimethyl ether Acylation; 2 h; Heating;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 50, # 3 p. 266 - 271
反应条件
hydrogenchloride; formaldehyd in ethanol; water Mannich reaction; Heating;
参考文献
Chemistry - A European Journal, , vol. 15, # 29 p. 7108 - 7116
反应条件
in ethanol 17 h; Heating;
参考文献
Farmaco, Edizione Scientifica, , vol. 39, # 6 p. 524 - 537
参考文献
WO2004/65376 A1, ;
Page/Page column 6 ;
反应条件
sodium cyanide in N,N-dimethyl-formamide Stetter reaction;
参考文献
Ogura, Katsuyuki; Yanai, Hiroyuki; Miokawa, Masazumi; Akazome, Motohiro
Tetrahedron Letters, 1999 , vol. 40, # 50 p. 8887 - 8891
反应条件
1: 70 percent / NaCN / dimethylformamide 2: 85 percent / ammonium acetate / acetic acid; acetic anhydride / Heating View Scheme
参考文献
Wynberg, Hans; Metselaar, Jan
Synthetic Communications, 1984 , vol. 14, # 1 p. 1 - 10
反应条件
1: 50 percent / sodium cyanide / dimethylformamide 2: 75 percent / Lawesson's reagent / toluene / Heating View Scheme
参考文献
Joshi, Makarand V.; Hemler, Christine; Cava, Michael P.; Cain, Jason L.; Bakker, Martin G.; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 6 p. 1081 - 1086
