1: With sodium hydroxide in 1,4-dioxane; water T=23°C; 1.5 h; 2: With potassium hydrogensulfate in 1,4-dioxane; water pH=5;

sodium hydroxide in water; tert-butyl alcohol 3 h; Ambient temperature;

暂无反应条件数据

1: 74.5 percent / SOCl2 / -20 - 20 °C 2: 97 percent / aq. NaOH / acetonitrile; H2O / 5 h / 37 - 42 °C / α-chymotrypsin 3: 93 percent / aq. HCl / 10 h / Heating 4: 85 percent / aq. NaOH / H2O; 2-methyl-propan-2-ol / 3 h / Ambient temperature View Scheme

1: 97 percent / aq. NaOH / acetonitrile; H2O / 5 h / 37 - 42 °C / α-chymotrypsin 2: 93 percent / aq. HCl / 10 h / Heating 3: 85 percent / aq. NaOH / H2O; 2-methyl-propan-2-ol / 3 h / Ambient temperature View Scheme

1: 93 percent / aq. HCl / 18 h / Heating 2: 95 percent / aq. NaOH / 0 °C 3: 74.5 percent / SOCl2 / -20 - 20 °C 4: 97 percent / aq. NaOH / acetonitrile; H2O / 5 h / 37 - 42 °C / α-chymotrypsin 5: 93 percent / aq. HCl / 10 h / Heating 6: 85 percent / aq. NaOH / H2O; 2-methyl-propan-2-ol / 3 h / Ambient temperature View Scheme

1: 93 percent / aq. HCl / 10 h / Heating 2: 85 percent / aq. NaOH / H2O; 2-methyl-propan-2-ol / 3 h / Ambient temperature View Scheme

1: 1.) NaOEt / 1.) EtOH, 30 min, 2.) EtOH, reflux, 18 h 2: 93 percent / aq. HCl / 18 h / Heating 3: 95 percent / aq. NaOH / 0 °C 4: 74.5 percent / SOCl2 / -20 - 20 °C 5: 97 percent / aq. NaOH / acetonitrile; H2O / 5 h / 37 - 42 °C / α-chymotrypsin 6: 93 percent / aq. HCl / 10 h / Heating 7: 85 percent / aq. NaOH / H2O; 2-methyl-propan-2-ol / 3 h / Ambient temperature View Scheme