3-氯-4-(吡啶-3-基)-1,2,5-噻二唑合成路线 （共 11 条）
反应条件
1: With disulfur dichloride in DMF (N,N-dimethyl-formamide); dichloromethane T=0 - 20°C; 48 h; 2: With potassium carbonate in water
参考文献
FMC CORPORATION
Patent: WO2005/6858 A2, 2005 ;
Location in patent: Page/Page column 32-33 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; toluene Suzuki cross-coupling reaction; 24 h; Heating;
参考文献
Merschaert, Alain; Gorissen, Hugo J.
Heterocycles, 2003 , vol. 60, # 1 p. 29 - 45
反应条件
1: aq. NH4Cl, NH3 2: S2Cl2 / dimethylformamide View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 22 p. 4378 - 4384
反应条件
Pd(tri-2-furylphosphine)4 in toluene Stille cross-coupling reaction; Heating;
参考文献
Merschaert, Alain; Gorissen, Hugo J.
Heterocycles, 2003 , vol. 60, # 1 p. 29 - 45
反应条件
Pd(tri-2-furylphosphine)4 in toluene Stille cross-coupling reaction; Heating;
参考文献
Merschaert, Alain; Gorissen, Hugo J.
Heterocycles, 2003 , vol. 60, # 1 p. 29 - 45
反应条件
tris-(dibenzylideneacetone)dipalladium(0) in toluene Stille cross-coupling reaction; 2 h; Heating;
参考文献
Merschaert, Alain; Gorissen, Hugo J.
Heterocycles, 2003 , vol. 60, # 1 p. 29 - 45
反应条件
1: aq. NH4Cl, 25percent aq. NH3 / 18 h / Ambient temperature 2: 1.) S2Cl2, 2.) aq. NaOH / 1.) DMF, 5 deg C, 30 min, 2.) 5 deg C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2274 - 2283
反应条件
potassium fluoride; anhydrous tetramethylammonium chloride in N,N-dimethyl acetamide
T=140°C; 6 h;
参考文献
FMC CORPORATION
Patent: WO2005/6858 A2, 2005 ;
Location in patent: Page/Page column 35 ;
反应条件
in tetrahydrofuran
T=-6 - 20°C; 0.583333 h;
参考文献
FMC CORPORATION
Patent: WO2005/6858 A2, 2005 ;
Location in patent: Page/Page column 33-34 ;
反应条件
in acetone
T=20°C; 18 h;
参考文献
FMC CORPORATION
Patent: WO2005/6858 A2, 2005 ;
Location in patent: Page/Page column 34 ;
