Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 22 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 45 °C 3: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C 4: tetrabutylammomium bromide; sodium hydrogencarbonate / acetonitrile / 26 h / Reflux; Large scale reaction View Scheme
参考文献
Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 22 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 45 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Large scale reaction
3.2: 0 °C / Large scale reaction
4.1: hydrazine hydrate / ethanol; tert-butyl methyl ether / 16 h / 40 °C
4.2: 40 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
View Scheme
参考文献
Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 22 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 45 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Large scale reaction
3.2: 0 °C / Large scale reaction
4.1: hydrazine hydrate / ethanol; tert-butyl methyl ether / 16 h / 40 °C
4.2: 40 °C
View Scheme
参考文献
Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
