7-溴-3,4-二氢-1H-2-萘酮合成路线 （共 8 条）
反应条件
1: With AlCl3, aluminium chloride in dichloromethane 0.283333 h; 2: With bromine in dichloromethane T=20°C; 1 h;
参考文献
Baylor University
Patent: US2009/76076 A1, 2009 ;
Location in patent: Page/Page column 20 ;
US 20090076076 A1
反应条件
AlCl3, aluminium chloride in dichloromethane T=0 - 5°C; Friedel Crafts Alkylation;
参考文献
WO2006/31676 A2, ;
Page/Page column 45 ;
WO 2006/031676 A2
反应条件
1: 2-(3-Bromo-phenyl)-acetic acid With oxalyl dichloride T=20°C; 5.08333 h; Heating / reflux; 2: ethene With AlCl3, aluminium chloride in dichloromethane T=0 - 5°C; Friedel Crafts reaction;
参考文献
WO2004/82678 A1, ;
Page/Page column 38-39 ;
WO 2004/082678 A1
反应条件
thionyl chloride in dichloromethane
参考文献
US5225596 A1, ;
US 5225596 A
反应条件
aluminium trichloride T=0°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 1 p. 133 - 137
反应条件
1: NaH / 0.75 h / Heating 2: 53 percent / EtONa / ethanol / 21.5 h / Heating View Scheme
参考文献
Pendergast; Johnson; Dickerson; Dev; Duch; Ferone; Hall; Humphreys; Kelly; Wilson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2279 - 2291
反应条件
1: H2O / ethanol / 80 °C
2: aq. Ba(OH)2 / 120 °C
View Scheme
参考文献
Cheung, Adrian Wai-Hing; Danho, Waleed; Swistok, Joseph; Qi, Lida; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Chu, Xin-Jie; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 133 - 137
反应条件
ammonium acetate; sodium cyanoborohydride in methanol
T=20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; GUO, Lei; TANG, Guozhi; WANG, Zhanguo; WONG, Jason Christopher; ZHANG, Weixing
Patent: WO2012/31993 A1, 2012 ;
Location in patent: Page/Page column 54 ;
WO 2012/031993 A1
