2,4-二氯-3-甲基吡啶合成路线 （共 5 条）
反应条件
1: 2,4-Dichloropyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: methyl iodide in tetrahydrofuran; hexane T=-78°C; 1 h;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2005/7647 A1, 2005 ;
Location in patent: Page/Page column 183; 184 ;
WO 2005/007647 A1
反应条件
1: 2,4-Dichloropyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: methyl iodide in tetrahydrofuran
参考文献
US2009/69305 A1, ;
Page/Page column 66 ;
US 20090069305 A1
反应条件
triethylamine; trichlorophosphate in dichloromethane T=0 - 20°C; 4 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2005/103049 A1, ;
Page/Page column 71-72 ;
反应条件
1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 0 - 20 °C / |Inert atmosphere 2: triethylamine; trichlorophosphate / dichloromethane / 5 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
European Journal of Organic Chemistry, , # 35 p. 6940 - 6952
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
2 h; Reflux; Product distribution / selectivity;
参考文献
CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita
Patent: WO2010/132999 A1, 2010 ;
Location in patent: Page/Page column 123; 157-158 ;
