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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
132127-31-2
合成路线
（共 13 条）
132127-31-2
→
反应条件
201856-48-6
(3R,4S)-3-(1-乙氧基乙氧基)-4-苯基-2-氮杂环丁酮
反应条件
1: 100 percent / NBu4F / tetrahydrofuran 2: 100 percent / H(1+) View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
98-88-4
苯甲酰氯
+
132127-31-2
→
反应条件
155371-59-8
紫杉醇侧链2
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C;
参考文献
Ojima, Iwao; Fumero-Oderda, Cecilia L.; Kuduk, Scott D.; Ma, Zhuping; Kirikae, Fumiko; Kirikae, Teruo
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2867 - 2888
132127-31-2
→
反应条件
33069-62-4
紫杉醇
反应条件
1: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 2: 100 percent / tetrahydrofuran / 2 h / 0 °C 3: 92 percent / DMAP, triethylamine / CH2Cl2 / 2 h / 25 °C 4: 40 percent / NaH / tetrahydrofuran / 3 h / 35 °C 5: 88 percent / 0.5percent hydrochloric acid / ethanol / 48 h / 0 °C View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
132127-31-2
→
反应条件
132201-33-3
N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸
反应条件
1: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 2: 100 percent / 6 N HCl / 12 h / Heating 3: 70 percent / NaHCO3 / CH2Cl2; H2O View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
132127-31-2
→
反应条件
132127-34-5
(3R,4S)-3-羟基-4-苯基-2-氮杂环丁酮
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152
132127-31-2
→
反应条件
132201-32-2
(2R,3S)-3-苯基异丝氨酸盐酸盐
反应条件
hydrogenchloride T=25°C; 5 h;
参考文献
Ojima, Iwao; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry; Zhao, Mangzhu
Tetrahedron Letters, 1992 , vol. 33, # 39 p. 5737 - 5740
132127-31-2
→
反应条件
125354-16-7
10-乙酰多西他赛
反应条件
1: 98 percent / Et3N; DMAP / CH2Cl2 / 20 °C 2: 64 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -30 °C 3: HF; pyridine / acetonitrile View Scheme
参考文献
Ojima, Iwao; Fumero-Oderda, Cecilia L.; Kuduk, Scott D.; Ma, Zhuping; Kirikae, Fumiko; Kirikae, Teruo
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2867 - 2888
132127-31-2
→
反应条件
133524-70-6
反应条件
1: 98 percent / Et3N; DMAP / CH2Cl2 / 20 °C 2: 64 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -30 °C 3: HF; pyridine / acetonitrile 4: 90 percent / TFA / CH2Cl2 / 0 °C View Scheme
参考文献
Ojima, Iwao; Fumero-Oderda, Cecilia L.; Kuduk, Scott D.; Ma, Zhuping; Kirikae, Fumiko; Kirikae, Teruo
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2867 - 2888
132127-31-2
→
反应条件
201856-53-3
(3R,4S)-1-苯甲酰-3-(1-乙氧乙氧基)-4-苯基-2-氮杂环丁酮
反应条件
1: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 2: 100 percent / tetrahydrofuran / 2 h / 0 °C 3: 92 percent / DMAP, triethylamine / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
132127-31-2
→
反应条件
149198-47-0
(3R,4S)-3-(三乙基硅氧基)-4-苯基-2-氧-氮杂环丁-1-甲酸叔丁酯
反应条件
1: 100 percent / NBu4F / tetrahydrofuran 2: pyridine 3: Et3N, DMAP / CH2Cl2 View Scheme
参考文献
Ojima, Iwao; Sun, Chung Ming; Zucco, Martine; Park, Young Boon; Duclos, Olivier; Kuduk, Scott
Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4149 - 4152
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