(3R,4S)-3-羟基-4-苯基-2-氮杂环丁酮合成路线 （共 32 条）
反应条件
hydrogen; palladium on activated charcoal
参考文献
Angewandte Chemie - International Edition, , vol. 41, # 5 p. 831 - 833
反应条件
water; sodium hydrogencarbonate in tetrahydrofuran T=20°C; 0.5 h; Product distribution / selectivity;
参考文献
US2006/281914 A1, ;
Page/Page column 10 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152
反应条件
sodium hydrogencarbonate; sodium carbonate Ambient temperature;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 6 p. 983 - 992
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=0°C; 0.25 h;
参考文献
Tetrahedron, , vol. 63, # 35 p. 8514 - 8520
反应条件
1: 95 percent / magnesium monoperoxyphthalate hexahydrate / methanol / 2 h 2: 72 percent / H2 / Pd/C / methanol; dioxane / 24 h / atmospheric pressure View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 23 p. 6111 - 6129
反应条件
1: 96 percent / magnesium monoperoxyphthalate hexahydrate / methanol / 2 h 2: 72 percent / H2 / Pd/C / methanol; dioxane / 24 h / atmospheric pressure View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 23 p. 6111 - 6129
反应条件
1: 74 percent / 5 h / 20 °C 2: 75 percent / Et3N / toluene / 8 h / 100 °C 3: 96 percent / magnesium monoperoxyphthalate hexahydrate / methanol / 2 h 4: 72 percent / H2 / Pd/C / methanol; dioxane / 24 h / atmospheric pressure View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 23 p. 6111 - 6129
反应条件
1: 80 percent / (NH4)2Ce(NO3)6 / H2O; acetonitrile / 1 h / 0 °C 2: 82 percent / methanolic NaHCO3, Na2CO3 / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 6 p. 983 - 992
反应条件
1: 1) LDA / 2a) THF, -78 deg C, 4 h, 2b) rt, overnight 2: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 5 p. 1681 - 1683
