(3R,4S)-3-羟基-4-苯基-2-氮杂环丁酮合成路线 （共 32 条）
反应条件
in tetrahydrofuran; hexane; acetone
参考文献
Florida State University
Patent: US5015744 A1, 1991 ;
反应条件
1: 100 percent / tetrahydrofuran / 2 h / 0 °C 2: 92 percent / DMAP, triethylamine / CH2Cl2 / 2 h / 25 °C 3: 40 percent / NaH / tetrahydrofuran / 3 h / 35 °C 4: 88 percent / 0.5percent hydrochloric acid / ethanol / 48 h / 0 °C View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
1: 6N hydrochloric acid / 3 h / 25 °C 2: 72 percent / NaHCO3 / CH2Cl2; H2O / 16 h / Ambient temperature View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Georg, Gunda I.; Jayasinghe, Lalith R.
Journal of Organic Chemistry, 1991 , vol. 56, # 5 p. 1681 - 1683
反应条件
hydrogenchloride in water
参考文献
The Research Foundation State University of New York
Patent: US5294737 A1, 1994 ;
反应条件
hydrogenchloride 12 h; Heating;
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Georg, Gunda I.; Jayasinghe, Lalith R.
Journal of Organic Chemistry, 1991 , vol. 56, # 5 p. 1681 - 1683
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
Florida State University
Patent: US5175315 A1, 1992 ;
反应条件
1: 100 percent / tetrahydrofuran / 2 h / 0 °C 2: 92 percent / DMAP, triethylamine / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
1: pyridine 2: Et3N, DMAP / CH2Cl2 View Scheme
参考文献
Ojima, Iwao; Sun, Chung Ming; Zucco, Martine; Park, Young Boon; Duclos, Olivier; Kuduk, Scott
Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4149 - 4152
反应条件
1H-imidazole in tetrahydrofuran T=0 - 20°C; 2.3 h;
参考文献
Walker; Swigor; Kant; Schroeder
Journal of Labelled Compounds and Radiopharmaceuticals, 1994 , vol. 34, # 10 p. 973 - 980
反应条件
1: 100 percent / H(1+) 2: 93 percent / Et3N, DMAP / CH2Cl2 View Scheme
参考文献
Ojima, Iwao; Sun, Chung Ming; Zucco, Martine; Park, Young Boon; Duclos, Olivier; Kuduk, Scott
Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4149 - 4152
