(3R,4S)-3-羟基-4-苯基-2-氮杂环丁酮合成路线 （共 32 条）
反应条件
1: 94 percent / pyridine 2: 98 percent / NEt3 View Scheme
参考文献
Brown, Stephen; Jordan, Allan M.; Lawrence, Nicholas J.; Pritchard, Robin G.; McGown, Alan T.
Tetrahedron Letters, 1998 , vol. 39, # 21 p. 3559 - 3562
反应条件
1: 90 percent / PPTS / acetone / 20 h
2: 1.) LiHMDS / 1.) THF, -40 deg C, 2.) THF, -40 deg C, 2 h
3: 100 percent / 0.1N HCl / tetrahydrofuran / 1 h / Ambient temperature
4: 80 percent / Me2S*Br2 / CH2Cl2 / 2 h / 0 °C
5: 95 percent / tetrahydrofuran / 3 h / -40 °C
6: 90 percent / TBAF / tetrahydrofuran / 2 h / 0 °C
View Scheme
参考文献
Kant, Joydeep; Schwartz, Wendy S.; Fairchild, Craig; Gao, Qi; Huang, Stella; Long, Byron H.; Kadow, John F.; Langley, David R.; Farina, Vittorio; Vyas, Dolatrai
Tetrahedron Letters, 1996 , vol. 37, # 36 p. 6495 - 6498
