2,4-二氨基-6-碘喹唑啉合成路线 （共 5 条）
反应条件
sodium ethanolate in ethanol T=80 - 150°C; 26 h;
参考文献
Khabnadideh, Soghra; Pez, Didier; Musso, Alexander; Brun, Reto; Ruiz Perez, Luis M.; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2637 - 2649
反应条件
1: With hydrogenchloride; sodium nitrite T=0°C; 0.25 h; 2: With potassium iodide T=0 - 70°C; Further stages.;
参考文献
Graffner-Nordberg; Kolmodin; Aqvist; Queener; Hallberg
Journal of Medicinal Chemistry, 2001 , vol. 44, # 15 p. 2391 - 2402
反应条件
in diethylene glycol dimethyl ether T=130°C; 3 h;
参考文献
Harris, NV; Smith, C; Bowden, K
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 1 p. 7 - 18
反应条件
1: 88 percent / iodine monochloride; acetic acid / 5 h / 20 °C 2: 90 percent / sodium ethoxide / ethanol / 26 h / 80 - 150 °C View Scheme
参考文献
Harris, NV; Smith, C; Bowden, K
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 1 p. 7 - 18
反应条件
1: 45 percent / palladium(II) acetate; tri-o-tolyl phosphine; piperidine / dimethylformamide / 60 h / 120 °C
2: 70 percent / H2 / palladium(II) hydroxide / dimethylformamide / 24 h / 20 °C
View Scheme
参考文献
Khabnadideh, Soghra; Pez, Didier; Musso, Alexander; Brun, Reto; Ruiz Perez, Luis M.; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2637 - 2649
