potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=70°C; 2 h;

1.1: lithium diisopropyl amide; N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 2.5 h / -60 - -50 °C 1.2: pH 2 - 3 2.1: sulfuric acid / Reflux 3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 2 h / 70 °C View Scheme

1: sulfuric acid / Reflux 2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 2 h / 70 °C View Scheme