1: N2O4, NaOAc / CCl4 / 0.25 h / 5 °C 2: LiBH4 / tetrahydrofuran / Ambient temperature 3: 83 g / pyridine / 2.5 h / Ambient temperature 4: 46.4 g / 0.5 N H2SO4 / acetonitrile / 17 h / Ambient temperature 5: 90 percent / LS-Selectride / tetrahydrofuran / 0.17 h / -78 °C 6: 84 percent / 8 h / 57 °C 7: 51 percent / K2CO3, 18-crown-6 / dimethylformamide / 21 h / 110 °C 8: 1.) NaOMe, 2.) 3N HCl / 1.) MeOH, 40 deg C, 2 h, 2.) 50 deg C, 2 h View Scheme

1: N2O4, NaOAc / CCl4 / 0.25 h / 5 °C 2: LiBH4 / tetrahydrofuran / Ambient temperature 3: 83 g / pyridine / 2.5 h / Ambient temperature 4: 46.4 g / 0.5 N H2SO4 / acetonitrile / 17 h / Ambient temperature 5: 90 percent / LS-Selectride / tetrahydrofuran / 0.17 h / -78 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: DCC / CH₂Cl₂ / Ambient temperature<br />2: imidazole / dimethylformamide / 1.5 h / 5 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103853', constants.ctx, '0')">1H-imidazole</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=5&deg;C;&nbsp;1.5&nbsp;h;&nbsp;<br /> &nbsp;