3-羟基-1-甲基四氢吡咯合成路线 （共 13 条）
反应条件
1: (-)-2-Cyclopentyl-2-hydroxy-2-phenylacetic acid; 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=70°C; 20 h; Inert atmosphere; 2: 3-hydroxy-1-methylpyrrolidine in N,N-dimethyl-formamide T=70°C; 24 h; Inert atmosphere;
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 19 h / 18 - 60 °C / |Inert atmosphere
2: toluene / 2 h / |Inert atmosphere
View Scheme
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
Mitsunobu reaction; 16 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2005/111038 A2, 2005 ;
Location in patent: Page/Page column 76 ;
WO 2005/111038 A2
