(2R,3S)-3-苯基异丝氨酸盐酸盐合成路线 （共 27 条）
反应条件
1: AcBr / CH2Cl2 / 2 h / -15 °C 2: NaN3 / dimethylformamide / 50 °C 3: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 4: 10percent aq. HCl / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 17 p. 5104 - 5105
反应条件
1: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 2: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 3: 6N hydrochloric acid / 3 h / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 34 p. 6985 - 7012
反应条件
1: 1. hexamethyldisilazane, n-BuLi / 1. THF, hexane, reflux, 3 h; 2. reflux, 2 h 2: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 3: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 4: 6N hydrochloric acid / 3 h / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 34 p. 6985 - 7012
反应条件
hydrogenchloride T=100°C; 4 h; Yield given;
参考文献
Angewandte Chemie (International Edition in English), , vol. 36, # 13-14 p. 1483 - 1486
反应条件
1: 81 percent / K2OsO2(OH)4; (DHQ)2-PHAL; LiOH 2: HCl / H2O / 4 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 58, # 14 p. 2777 - 2787
反应条件
1: 1) LDA / 2a) THF, -78 deg C, 4 h, 2b) rt, overnight 2: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 3: 100 percent / 6 N HCl / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 5 p. 1681 - 1683
反应条件
1: 1.) LDA / 2.) THF, -95 deg C to -78 deg C 2: cerium ammonium nitrate / tetrahydrofuran 3: 98 percent / 6N hydrochloric acid / 5 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5737 - 5740
反应条件
1: cerium ammonium nitrate / tetrahydrofuran 2: 98 percent / 6N hydrochloric acid / 5 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5737 - 5740
反应条件
1: With sulfuric acid; acetonitrile T=-10 - 20°C; 2 h; 2: With hydrogenchloride 2 h; Heating;
参考文献
Tetrahedron Letters, , vol. 44, # 2 p. 407 - 409
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 59, # 17 p. 5104 - 5105
