1: in ethyl acetate T=78°C; 5.33333 h; Heating / reflux; 2: With hydroxylammonium sulphate in water; ethyl acetate T=71°C; Heating / reflux; 3: With sodium carbonate in water; ethyl acetate T=71°C; pH=6.5 - 7.0; 7 h; Heating / reflux;

hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine in ethanol

1: 1-methyl-pyrrolidin-2-one / 20 °C / |Inert atmosphere 2: hydroxylamine hydrochloride; triethylamine / methanol / 20 - 45 °C / |Inert atmosphere 3: triethylamine / acetonitrile / 0.5 h / 20 - 35 °C / |Inert atmosphere 4: ethanol / 5.5 h / |Inert atmosphere; |Reflux View Scheme

3,5-dimethyl pyridine; dimethyl sulfoxide in acetonitrile T=20°C; 12 h; Product distribution / selectivity;