5-(三甲基硅烷基)-4-戊炔-1-醇合成路线 （共 21 条）
反应条件
1.1: DIBAL-H / diethyl ether; hexane / 24 h / Heating 1.2: 91 percent / I2 / diethyl ether; hexane / 2 h / -78 °C 2.1: CuCN / diethyl ether / 0.25 h / 0 °C 2.2: 97 percent / diethyl ether / 20 h / 0 °C 3.1: 94 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 20 °C View Scheme
参考文献
Heffron, Timothy P.; Jamison, Timothy F.
Organic Letters, 2003 , vol. 5, # 13 p. 2339 - 2342
反应条件
1H-imidazole; iodine; triphenylphosphine in tetrahydrofuran T=20°C;
参考文献
Rodier, Fabien; Rajzmann, Michel; Parrain, Jean-Luc; Chouraqui, Gaelle; Commeiras, Laurent
Chemistry - A European Journal, 2013 , vol. 19, # 7 p. 2467 - 2477
反应条件
potassium carbonate; AgCl; tetrakis(trimethylphosphane)palladium(0) in methanol; N,N-dimethyl-formamide T=40°C;
参考文献
Halbes, Ulla; Pale, Patrick
Tetrahedron Letters, 2002 , vol. 43, # 11 p. 2039 - 2042
反应条件
La[N(TMS)2]3 in benzene-d6
T=60°C; 5 h; Inert atmosphere;
参考文献
Seo, SungYong; Yu, Xianghua; Marks, Tobin J.
Journal of the American Chemical Society, 2009 , vol. 131, p. 263 - 276
参考文献
Brinkmann, Christine; Barrett, Anthony G. M.; Reid, Stephanie; Hill, Michael S.; Procopiou, Panayiotis A.
Organometallics, 2012 , vol. 31, # 20 p. 7287 - 7297,11
反应条件
carbon tetrabromide; triphenylphosphine in diethyl ether
T=20°C; 48 h;
参考文献
Nishimoto, Yoshihiro; Kajioka, Masayuki; Saito, Takahiro; Yasuda, Makoto; Baba, Akio
Chemical Communications, 2008 , # 47 p. 6396 - 6398
反应条件
pyridine-SO3 complex
参考文献
Makabe, Hidefumi; Higuchi, Masaharu; Konno, Hiroyuki; Murai, Masatoshi; Miyoshi, Hideto
Tetrahedron Letters, 2005 , vol. 46, # 27 p. 4671 - 4675
Title/Abstract Full Text View citing articles Show Details
Makabe, Hidefumi; Kimura, Yuka; Higuchi, Masaharu; Konno, Hiroyuki; Murai, Masatoshi; Miyoshi, Hideto
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 3119 - 3130
反应条件
1: 1.) PCC, 3A MS, 2.) NH2OH*HCl / 1.) CH2Cl2, 0 deg C, 8 h, 2.) EtOH, H2O, 30 min
2: NaCNBH3, pH 3-4, HCl, methyl orange / methanol / 0.08 h / -10 °C
3: benzene / 16 h / Heating
View Scheme
参考文献
Fox, Martin E.; Holmes, Andrew B.; Forbes, Ian T.; Thompson, Mervyn
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 23 p. 3379 - 3396
反应条件
1: trans vinyl bromide With tert.-butyl lithium in diethyl ether; pentane
T=-78 - 20°C; 1 h;
2: 5-trimethylsilanyl-pent-4-yn-1-ol in diethyl ether; pentane
T=-78 - -20°C; 1.66667 h;
参考文献
Miyamoto, Hiroshi; Hirano, Tomohiro; Okawa, Yoichiro; Nakazaki, Atsuo; Kobayashi, Susumu
Tetrahedron, 2013 , vol. 69, # 45 p. 9481 - 9493
反应条件
1: 96 percent / SO3*pyridine
2: 98 percent / tetrahydrofuran / 0.25 h / 0 °C
View Scheme
参考文献
Makabe, Hidefumi; Higuchi, Masaharu; Konno, Hiroyuki; Murai, Masatoshi; Miyoshi, Hideto
Tetrahedron Letters, 2005 , vol. 46, # 27 p. 4671 - 4675
