1: 1) NaH / 1a) THF, 0 deg C, 30 min, 1b) 25 deg C, 2.5h, 2a) 0 deg C, 1.5h, 2b) 25 deg C, 21.5h 2: 86 percent / LiOH-H2O / tetrahydrofuran; methanol; H2O / 65 h / 75 °C 4: 80 percent / 5percent HCl / tetrahydrofuran / 216 h / 25 °C View Scheme