1: acetonitrile / 48 h / |Reflux; |Inert atmosphere 2: caesium carbonate / tetrahydrofuran / 4 h / 55 °C 3: CHIRALPAK IA / diethylamine; methanol / |Resolution of racemate View Scheme

1: acetonitrile / 48 h / Reflux; Inert atmosphere 2: caesium carbonate / tetrahydrofuran / 4 h / 55 °C 3: CHIRALPAK IA column / diethylamine; carbon dioxide; methanol / Resolution of racemate View Scheme

1: acetonitrile / 48 h / |Reflux; |Inert atmosphere 2: caesium carbonate / tetrahydrofuran / 4 h / 55 °C 3: CHIRALPAK IA / diethylamine; methanol / |Resolution of racemate View Scheme

1: acetonitrile / 48 h / Reflux; Inert atmosphere 2: caesium carbonate / tetrahydrofuran / 4 h / 55 °C 3: CHIRALPAK IA column / diethylamine; carbon dioxide; methanol / Resolution of racemate View Scheme

1: acetonitrile / 48 h / Reflux; Inert atmosphere 2: caesium carbonate / tetrahydrofuran / 4 h / 55 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4933273', constants.ctx, '0')">hydrazine hydrate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=20 - 60&deg;C;&nbsp;20&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: acetic anhydride; triethylamine / dichloromethane; 2-methyl tetrahydrofuran / 20 - 95 &deg;C / Industry scale<br />2: hydrazine hydrate; acetic acid / tetrahydrofuran / 20 h / 20 - 60 &deg;C / Inert atmosphere<br /> <br /> &nbsp;