2-(2-吡啶基)-1H-吲哚合成路线 （共 36 条）
反应条件
1.1: 76 percent / aq. NaOH; tetrabutylammonium bromide / benzene / 2 h / 20 °C 2.1: LDA / tetrahydrofuran; cyclohexane / 0.5 h / 0 °C 2.2: ZnCl2 / tetrahydrofuran; cyclohexane / 0.5 h / 20 °C 2.3: 97 percent / Pd(PPh3)2Cl2; diisobutylaluminum hydride / hexane; tetrahydrofuran; cyclohexane / 6 h / Heating 3.1: 80 percent / aq. NaOH / ethanol / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 122, # 15 p. 3671 - 3678
反应条件
1.1: LDA / tetrahydrofuran; cyclohexane / 0.5 h / 0 °C 1.2: ZnCl2 / tetrahydrofuran; cyclohexane / 0.5 h / 20 °C 1.3: 97 percent / Pd(PPh3)2Cl2; diisobutylaluminum hydride / hexane; tetrahydrofuran; cyclohexane / 6 h / Heating 2.1: 80 percent / aq. NaOH / ethanol / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 122, # 15 p. 3671 - 3678
反应条件
1: With palladium diacetate; dimethyl sulfoxide; trifluoroacetic acid T=90°C; 24 h; 2: With iron T=90°C; 2 h;
参考文献
Synlett, , vol. 23, # 17 p. 2511 - 2515,5
Synlett, , vol. 23, # 17 p. 2511 - 2515
反应条件
1: in ethanol 0.416667 h; Heating; 2: With zinc(II) chloride T=140 - 150°C; Fischer synthesis; 0.0416667 h; microwave irradiation; Further stages.;
参考文献
Tetrahedron Letters, , vol. 45, # 48 p. 8831 - 8834
反应条件
in tetrahydrofuran 8 h; -78 degC then allowed to reach room temperature;
参考文献
Gribble, Gordon W.; Johnson, David A.
Tetrahedron Letters, 1987 , vol. 28, # 44 p. 5259 - 5262
反应条件
1: methyl pyridin-2-yl ketone With potassium tert-butylate in dimethyl sulfoxide 0.25 h; 2: 2-iodo aniline in dimethyl sulfoxide 3 h; Photolysis;
参考文献
Barolo, Silvia M.; Lukach, Andres E.; Rossi, Roberto A.
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2807 - 2811
反应条件
tetrakis(triphenylphosphine) palladium(0); tert.-butyl lithium; zinc(II) chloride Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 36, # 5 p. 941 - 942
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane Suzuki coupling; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2586 - 2590
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 6 h / 20 - 40 °C / |Inert atmosphere; |Schlenk technique 2: Au/Carbon G-60 catalyst / toluene / 48 h / 120 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 45 p. 11835 - 11839
Angew. Chem., , vol. 125, # 45 p. 12051 - 12055,5
反应条件
tert.-butyl lithium; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) 1.) pentane, -70 deg C, 1.5 h; -70 deg C to r.t., 2 h, 2.) THF, r.t., 28 h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 1927 - 1934
