3-(4-甲基-1H-吡咯-3-基)丙酸乙酯合成路线 （共 10 条）
反应条件
potassium hydroxide; acetic acid in methanol; diazomethane-ether; diethyl ether; ethanol; water
参考文献
Sugen, Inc.
Patent: US6395734 B1, 2002 ;
US 6395734 B1
反应条件
T=180°C; P=2 Torr; 5 h;
参考文献
Nogales, Daniel F.; Timothy Anstine; Lightner, David A.
Tetrahedron, 1994 , vol. 50, # 29 p. 8579 - 8596
反应条件
1: 90 percent / H2 / Raney nickel / aq. NaOH / 12 h / 1551.4 Torr / Ambient temperature 2: 88 percent / SO2Cl2 / diethyl ether / -15 deg C, 1h, then 0 deg C, 4h 3: 1.) 10percent aq. NaOH / 1.) 180 deg C, 90 min, 2.) EtOH, ether View Scheme
参考文献
Tetrahedron, , vol. 46, # 22 p. 7599 - 7659
反应条件
1: 88 percent / SO2Cl2 / diethyl ether / -15 deg C, 1h, then 0 deg C, 4h 2: 1.) 10percent aq. NaOH / 1.) 180 deg C, 90 min, 2.) EtOH, ether View Scheme
参考文献
Tetrahedron, , vol. 46, # 22 p. 7599 - 7659
反应条件
1: 1.) SO2Cl2; 2.) NaOH 2: 98 percent / CF3CO2H 3: 81 percent / Heating View Scheme
参考文献
Tetrahedron, , vol. 50, # 29 p. 8579 - 8596
反应条件
1: 98 percent / CF3CO2H 2: 81 percent / Heating View Scheme
参考文献
Tetrahedron, , vol. 50, # 29 p. 8579 - 8596
反应条件
1: 10percent aq. NaOH / 3 h / Heating 2: 1) TFA / 1) TFA, EtOH, overnight, 2) RT, 48 h 3: 81 percent / 5 h / 180 °C / 2 Torr View Scheme
参考文献
Tetrahedron, , vol. 49, # 11 p. 2185 - 2200
反应条件
sodium hydroxide 1.) 180 deg C, 90 min, 2.) EtOH, ether; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 46, # 22 p. 7599 - 7659
反应条件
1: POCl3 / diethyl ether / Ambient temperature 2: NaOH / H2O / 0.5 h / Heating View Scheme
参考文献
Xie, Meiqiang; Lightner, David A.
Tetrahedron, 1993 , vol. 49, # 11 p. 2185 - 2200
反应条件
sodium hydroxide; trichlorophosphate 1.) diethylether, 0 deg C; 2.) H2O, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nogales, Daniel F.; Timothy Anstine; Lightner, David A.
Tetrahedron, 1994 , vol. 50, # 29 p. 8579 - 8596
