(4-(羟基甲基)-四氢-2H-吡喃-4-基)甲烷磺酸盐合成路线 （共 4 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 18 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 64 ;
US 20080009465 A1
反应条件
sodium iodide in acetone 20 h; Heating / reflux;
参考文献
PROSIDION LIMITED
Patent: WO2006/16174 A1, 2006 ;
Location in patent: Page/Page column 14 ;
WO 2006/016174 A1
反应条件
lithium bromide in water; acetone
参考文献
Targacept, Inc.
Patent: US2004/220214 A1, 2004 ;
反应条件
1: n-BuLi; diisopropylamine / tetrahydrofuran / -78 °C
2: HBr / 100 °C / pressure
View Scheme
参考文献
Bencherif; Schmitt; Bhatti; Crooks; Caldwell; Lovette; Fowler; Reeves; Lippiello
Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 284, # 3 p. 886 - 894
