2,5-二(羟基甲基)-3,4-吡咯烷二醇合成路线 （共 53 条）
反应条件
hydrogen; palladium dihydroxide in acetic acid
T=20°C; Hydrogenolysis; P=760 Torr; 18 h;
参考文献
Dondoni, Alessandro; Perrone, Daniela
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9375 - 9378
反应条件
hydrogen; palladium on activated charcoal in water
P=2585.7 Torr; 24 h;
参考文献
Liu, Kevin K.-C.; Kajimoto, Tetsuya; Chen, Lihren; Zhong, Ziyang; Ichikawa, Yoshitaka; Wong, Chi-Huey
Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6280 - 6289
参考文献
Kajimoto, Tetsuya; Chen, Lihren; Liu, Kevin K.-C.; Wong, Chi-Huey
Journal of the American Chemical Society, 1991 , vol. 113, # 18 p. 6678 - 6680
反应条件
hydrogen; rhodium on alumina in water
P=775.7 Torr; 3 h;
参考文献
Takayama, Shuichi; Martin, Richard; Wu, Jiangyue; Laslo, Karen; Siuzdak, Gary; Wong, Chi-Huey
Journal of the American Chemical Society, 1997 , vol. 119, # 35 p. 8146 - 8151
反应条件
hydrogenchloride; palladium dihydroxide; water; hydrogen in methanol
T=20°C; 48 h;
参考文献
Tsou, En-Lun; Yeh, Yao-Ting; Liang, Pi-Hui; Cheng, Wei-Chieh
Tetrahedron, 2009 , vol. 65, # 1 p. 93 - 100
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 4 h;
参考文献
Izquierdo, Isidoro; Plaza, Maria T.; Yanez, Victor
Tetrahedron, 2007 , vol. 63, # 6 p. 1440 - 1447
反应条件
1: With boron trifluoride diethyl etherate in dichloromethane
T=-78 - 20°C; 4.08333 h; Inert atmosphere;
2: With methanol
T=20°C; 12 h; stereoselective reaction;
参考文献
Donohoe, Timothy J.; Cheeseman, Matthew D.; O'Riordan, Timothy J. C.; Kershaw, Jessica A.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 21 p. 3896 - 3898
反应条件
1: NaBH4
2: H2 / hydrogenation catalyst
View Scheme
参考文献
Yu, Jaehoon; Choi, So Young; Lee, Sungsoo; Yoon, Hyun Joo; Jeong, Sunjoo; Mun, Hansuh; Park, Hokoon; Schultz, Peter G.
Chemical Communications, 1997 , # 20 p. 1957 - 1958
反应条件
1: 54 percent / KBr; AcOOH; NaOAc / acetic acid / 20 - 40 °C
2: 65 percent / Li / liquid ammonia; tetrahydrofuran / 1.5 h / -78 °C
View Scheme
参考文献
Restorp, Per; Fischer, Andreas; Somfai, Peter
Journal of the American Chemical Society, 2006 , vol. 128, # 39 p. 12646 - 12647
反应条件
1: pyridine / CH2Cl2 / -25 - 20 °C
2: 378 mg / NaN3 / dimethylformamide / 3 h / 20 °C
3: 95 percent / trifluoroacetic acid / H2O / 0.5 h / 20 °C
4: 96 percent / HCl; hydrogen / Pd/C / methanol; H2O / 3000.24 Torr
View Scheme
参考文献
Garcia-Moreno, M. Isabel; Aguilar, Matilde; Mellet, Carmen Ortiz; Garcia Fernandez, Jose M.
Organic Letters, 2006 , vol. 8, # 2 p. 297 - 299
